Wednesday, August 5, 2009
Hello Toronto! I’m in town for the APA conference (yes, the American Psychological Association is having its annual meeting in Canada).
Check out my photos from when I was in Toronto this past December.
Also, here’s what I’ll be presenting:
Amphetamine-induced changes in dendritic morphology in rat forebrain correspond to associative drug conditioning rather than nonassociative drug sensitization
BACKGROUND: Systemic exposure to amphetamine (AMPH) leads to a number of long-lasting neuroadaptations including changes in dendritic morphology in rat forebrain. It remains unknown whether these changes relate to associative drug conditioning or to nonassociative drug sensitization, two forms of plasticity produced by systemic exposure to AMPH. METHODS: We compared the behavioral, neuronal, and morphologic consequences of exposing rats to intraperitoneal (IP) AMPH to those of exposure to AMPH applied to the ventral tegmental area (VTA), infusions that sensitize AMPH-induced locomotion and nucleus accumbens (NAcc) DA overflow but do not produce drug conditioning. RESULTS: Both IP and VTA AMPH exposure sensitized locomotion and NAcc DA overflow, but only IP AMPH exposure produced conditioned locomotion. Importantly, whereas IP AMPH exposure increased spine density and dendritic length and branching in the NAcc, exposure to VTA AMPH produced the opposite effects. A similar differentiation of effects was observed in cortical areas. CONCLUSIONS: Together these findings suggest that the morphological changes seen following IP AMPH exposure reflect associative drug conditioning rather than nonassociative drug sensitization. The decreases observed in the NAcc of VTA AMPH exposed rats may reflect the inability of these infusions to support conditioning.

Hello Toronto! I’m in town for the APA conference (yes, the American Psychological Association is having its annual meeting in Canada).

Check out my photos from when I was in Toronto this past December.

Also, here’s what I’ll be presenting:

Amphetamine-induced changes in dendritic morphology in rat forebrain correspond to associative drug conditioning rather than nonassociative drug sensitization

BACKGROUND: Systemic exposure to amphetamine (AMPH) leads to a number of long-lasting neuroadaptations including changes in dendritic morphology in rat forebrain. It remains unknown whether these changes relate to associative drug conditioning or to nonassociative drug sensitization, two forms of plasticity produced by systemic exposure to AMPH. METHODS: We compared the behavioral, neuronal, and morphologic consequences of exposing rats to intraperitoneal (IP) AMPH to those of exposure to AMPH applied to the ventral tegmental area (VTA), infusions that sensitize AMPH-induced locomotion and nucleus accumbens (NAcc) DA overflow but do not produce drug conditioning. RESULTS: Both IP and VTA AMPH exposure sensitized locomotion and NAcc DA overflow, but only IP AMPH exposure produced conditioned locomotion. Importantly, whereas IP AMPH exposure increased spine density and dendritic length and branching in the NAcc, exposure to VTA AMPH produced the opposite effects. A similar differentiation of effects was observed in cortical areas. CONCLUSIONS: Together these findings suggest that the morphological changes seen following IP AMPH exposure reflect associative drug conditioning rather than nonassociative drug sensitization. The decreases observed in the NAcc of VTA AMPH exposed rats may reflect the inability of these infusions to support conditioning.

Friday, July 24, 2009 Monday, July 6, 2009 Thursday, June 25, 2009 Monday, May 4, 2009
Dolphins Maintain Round-The-Clock Visual Vigilance (via ScienceDaily)

Dolphins have a clever trick for overcoming sleep deprivation. Sam Ridgway from the US Navy Marine Mammal Program explains that they are able to send half of their brains to sleep while the other half remains conscious. What is more, the mammals seem to be able to remain continually vigilant for sounds for days on end.

Dolphins Maintain Round-The-Clock Visual Vigilance (via ScienceDaily)

Dolphins have a clever trick for overcoming sleep deprivation. Sam Ridgway from the US Navy Marine Mammal Program explains that they are able to send half of their brains to sleep while the other half remains conscious. What is more, the mammals seem to be able to remain continually vigilant for sounds for days on end.


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